CBD (Cannabidiol) How it Helps Retinitis Pigmentosa And Where to Buy It

Read the Case Study below for additional information on the validity of CBD

Dr. Andy Rosenfarb-Retintis Pigmentosa Treatment - July 7, 2018
THIS STUDY IS ON EYE PRESSURE BUT THERE IS RELEVANT CONTENT ON CBD OIL FOR RP:
Effect of sublingual application of cannabinoids on intraocular pressure: a pilotstudy.
Tomida I1, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ.
Author information
Abstract
PURPOSE:
The purpose of this study was to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Delta-9-THC) and cannabidiol (CBD).
PATIENTS AND METHODS:
A randomized, double-masked, placebo-controlled, 4 way crossover study was conducted at a single center, using cannabis-based medicinal extract of Delta-9-THC and CBD. Six patients with ocular hypertension or early primary open angle glaucoma received a single sublingual dose at 8 AM of 5 mg Delta-9-THC, 20 mg CBD, 40 mg CBD, or placebo. Main outcome measure was IOP. Secondary outcomes included visual acuity, vital signs, and psychotropic effects.
RESULTS:
Two hours after sublingual administration of 5 mg Delta-9-THC, the IOP was significantly lower than after placebo (23.5 mm Hg vs. 27.3 mm Hg, P=0.026). The IOP returned to baseline level after the 4-hour IOP measurement. CBD administration did not reduce the IOP at any time. However, the higher dose of CBD (40 mg) produced a transient elevation of IOP at 4 hours after administration, from 23.2 to 25.9 mm Hg (P=0.028). Vital signs and visual acuity were not significantly changed. One patient experienced a transient and mild paniclike reaction after Delta-9-THC administration.
CONCLUSIONS:
A single 5 mg sublingual dose of Delta-9-THC reduced the IOP temporarily and was well tolerated by most patients. Sublingual administration of 20 mg CBD did not reduce IOP, whereas 40 mg CBD produced a transient increase IOP rise.
PMID: 16988594 DOI: 10.1097/01.ijg.0000212260.04488.6
Many People Suffer with Eye Pressure Problems
Could CBD oil help with eye pressure problems? The optic nerve transmits visual information from the retina to the brain. If the pressure within the eye – known as intraocular pressure (IOP) – increases, then it can lead to a slow loss of nerve fibers within the optic nerve and ultimately lead to irreversible blindness. When an increase in eye pressure causes damage to the optic nerve, it gives rise to a condition called glaucoma. Over 3 million Americans have glaucoma, of which many diagnosed individuals are required to use eye drops on a daily basis.
Over the years, with advancements in medical science, topical treatments and surgeries have cut the risk of blindness from glaucoma by nearly half. To manage high intraocular eye pressure, people have also relied on complementary therapies, including eye exercises, yoga, regular physical activity and a diet rich in green, leafy vegetables.
Studies on the Use of CBD for Intraocular Pressure
There are numerous studies showing the benefit of CBD in addressing inflammatory diseasesand reducing pain, nausea, anxiety and insomnia. These symptoms are also associated with glaucoma, offering hope that CBD can assist individuals living with high eye pressure in a meaningful way.
In one of the earliest studies observing the effect of cannabis on IOP, researchers found that smoking marijuana could lower pressure by 25%-30%. Since these studies, many other have confirmed the ability of different types of cannabinoids, including cannabidiol, endogenous cannabinoids and cannabigerol, to reduce IOP when administered topically and systematically.
A study titled Localization of cannabinoid CB1 receptors in the human anterior eye and retina has confirmed the widespread distribution of cannabinoid CB1 receptors in the anterior eye and retina, suggesting that cannabinoids affect various physiological functions in the human eye.
In a 1979 study published in the International Journal of Pharmacology and Biopharmacology, 16 patients suffering from open-angle glaucoma, which is caused by the slow clogging of the drainage canals, experienced positive results after using CBD. CBD was found to reduce blood pressure and trigger an increase in heart rate, the combined effect of which lowered intraocular pressure. The effects of CBD sustained longer in patients with hypertension.
Increasing Interest in Cannabinoid-Derived Medication for Glaucoma
Unlike eye drops, cannabis cannot be consumed every 3-4 hours as it may cause unhealthy dependency and a use disorder.
In late-stage glaucoma, where doctors are most concerned with alleviating symptoms, the use of medical marijuana is viewed positively. Patients can enjoy significant pain relief and avoid excessive nausea, though they may not be able to do much about the condition itself.
Cannabinoids have also been seen to have protective effects against retinal damage. Damage to the retina can occur with the aging process. Though vitamins can help counteract some of the damage, degeneration from a progression in age is difficult to stem entirely. The good news is that research has indicated that cannabinoids may function as neuropathic agents and help in slowing down loss of vision resulting from retinal conditions such as retinitis pigmentosa. Studies have also suggested the ability of cannabinoid in enhancing the sensitivity of retinal cells to light, improving low-light vision and blazing a path towards more research on the use of medical cannabis in the treatment of degenerative eye diseases.
Cannabinoid receptors are prominent in eye tissues that regulate intraocular pressure. In the future, cannabinoid-derived medication can target these tissues to reduce IOP and increase the survival of eye cells. What works in CBD’s favor is that it is well-tolerated when applied topically, which means the potential for topical CBD preparations is high. The challenge will be to ensure that the medications penetrate intraocular tissues effectively.
Does cannabidiol oil lower or raise eye pressure?
OCT 23, 2017
Question:
Does cannabidiol oil lower or raise eye pressure? I have read both. If I am taking Lumigan for glaucoma already, will CBD oil hurt or help me? I want to take CBD for stress and anxiety, but not at the expense of my eyes.
Answer:
We’ve known since the 1970s that smoking marijuana lowers intraocular pressure. The effect is relatively short-acting and not as potent as other FDA-approved pressure- lowering medications. Most of the studies since that time have focused on the cannabinoid, ∆-9-tetrahydrocannabinol (Delta-9-THC), which does lower intraocular pressure, but is the main psychoactive constituent of cannabis. Cannabidiol (CBD) oil has been less rigorously studied, and most of that data is in animal models.
So, the best answer I can give you is that it is hard to say. I have not read anything to suggest that CBD oil will alter the effectiveness of Lumigan, but I don’t think it is unreasonable to try it. If you do find that the CBD oil is useful for stress and anxiety, then I would carefully follow you for several months to determine if usage is accompanied by deleterious effects on your intraocular pressure (or otherwise).